SIM1
In mice, a mutation in this gene causes there to be fewer neurons in an area of the brain called the paraventricular nucleus, where MC4R is expressed. These mice ate large amounts of food, were obese, and had increased height (or length depending on how you look at it). A case report of a young girl who had mutations in this gene had severe early onset obesity. She would eat a lot and weighed 44 lbs at 2 years old and 88 lbs by 5 years old. She also had a rapid increase in her height. She did not have any of the other symptoms typical of genetic obesity disorders. Return to Genetics or the
Home Page.
It is important you
discuss any weight loss or exercise plan with your doctor. Only you and
your physician can decide what is best for you. Some people have
certain conditions that prevent them from doing all exercises, and goal
body weights may be different for different people. You need to discuss
all these things with your physician before starting any weight loss or
exercise program. This article was written by John Vickery, MD. References Endocrinol Metab Clin N Am 2008;37:733-751
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