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Pyruvate


Pyruvate is made in our bodies and is a key step in the metabolism of sugar (glucose) into energy. Some people, like bodybuilders or others in training, use this supplement to try to increase the transport of glucose into muscle cells.

In one study on it use in weight loss at a dose of 6 grams per day there was an association with a weight loss of 2 lb 10 oz after 6 weeks. This study only had 26 people, and they exercised 3 days per week.

The weight loss mentioned above was the difference from the placebo group. However, the total lean body mass was not different between the two groups. This does not support using it to build muscle mass. Other studies have shown no weight loss with pyruvate.

It can cause gastrointestinal side effects like gas, bloating, and diarrhea. To try to avoid these problems, manufacturers combine it with calcium, sodium, or magnesium.


 


It is important you discuss any weight loss or exercise plan with your doctor. Only you and your physician can decide what is best for you. Some people have certain conditions that prevent them from doing all exercises, and goal body weights may be different for different people. You need to discuss all these things with your physician before starting any weight loss or exercise program.


This article was written by John Vickery, MD.


References

Am Fam Physician. 2004 Nov 1;70(9):1731-8.
Lexi-Comp database accessed on 4/26/08.
Nutrition. 1999 May;15(5):337-40. (abstract only)
Int J Obes (Lond). 2005 Sep;29(9):1030-8.