Proenzyme Convertase 1
Children with this mutation eat large amounts of food. They can weigh more than 77 lbs by 3 years old. POMC is made into ACTH which signals the production of cortisol. Because of this, PC-1 deficiency causes low cortisol levels. Glucagon stimulates the lining of the small intestine to grow. Less glucagon leads to decreased absorbing capacity of the small intestine. Only 3 cases have been reported.
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It is important you
discuss any weight loss or exercise plan with your doctor. Only you and
your physician can decide what is best for you. Some people have
certain conditions that prevent them from doing all exercises, and goal
body weights may be different for different people. You need to discuss
all these things with your physician before starting any weight loss or
exercise program. This article was written by John Vickery, MD. References Fauci et al., Harrison's Principles of Internal Medicine 17th ed., ch 74 Endocrinol Metab Clin N Am 2008;37:733-751
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