Basics

Mesotherapy,
also known as intradermotherapy, is really a term that describes a way
to deliver medicines. Medicines and/or other substances are injected
into the connective tissue that is just under the skin (the mesoderm).
It is used in the treatment of several different diseases and
conditions. What is generally thought of when hearing this term is the
injection of medicines under the skin to dissolve fat and
cellulite.
Its use in body shaping has been employed in Europe and South America
for several years. It is beginning to show up in "wellness centers" and
"medical spas" in the US.
Mesotherapy has also gone be the names lipodissolve, lipotherapy, lipolyse, thinjection, phospholipon, and lipolight.
Generally, a numbing cream is applied
to the skin over the area to be treated. Then, multiple injections with
small needles (either by syringes or a special gun) are made a various
skin levels. There can be up to several hundred injections.
Diet,
exercise, and
nutritional supplements are often used in addition.

There
are several different medicines and substances that have been used in
the injections. They vary depending on the intended treatment and the
person performing the therapy. Two of the most popular substances
are discussed below. Click on each one for more information.
Phosphatidylcholine (or lecithin) for mesotherapy
Isoproterenol for mesotherapy
Side effects
Side
effects are usually only at the sites of injection and only last for a
short time. The most common ones are swelling, tenderness, and bruising
in the areas of the injections. Some other side effects are
infections, drug reactions, bleeding, inflammation, ulcer formation,
and hematoma formation.
Other CommentsMesotherapy not
a conventional technique taught in US medical schools. It is mainly
used in Europe for the treatment of pain. Make sure you have fully
discussed this with your doctor, and make sure the doctor performing
it has a good understanding of how it should be given. Also, some
unlicensed practitioners have used this technique. The bottom line is
to only go to someone who knows what he/she is doing.

The main
effect of dissolving fat occurs on the fat stored inside the fat cells.
The cells themselves are generally still there. They just have less fat
in them after the injections. Since they did not go away, they can fill
up with and store fat again later.
There is no
FDA approved drug to be used in mesotherapy for body shaping. The compounds are either being used
"off-label"
or have no FDA approved indication at all. Most of the components of
the injections are based more off personal experience than scientific
data.
It has not been studied as much as other weight loss
therapies. The long term safety and efficacy have not been established.
More studies need to be performed to better understand the full effects.
It is important you discuss any weight loss or exercise plan with your doctor. Only you and your physician can decide what is best for you. Some people have certain conditions that prevent them from doing all exercises, and goal body weights may be different for different people. You need to discuss all these things with your physician before starting any weight loss or exercise program. In addition, the dosage of any medicine may be different if it is used for weight loss and not its FDA approved indication. You should also discuss this with your doctor.
This
article was written by
John
Vickery, MD.
References
Plast Reconstr Surg. 2005 April 15;115(5):1420-4
Dermatol Surg. 2006 Apr;32(4):465-80

Last updated: 3/10/2008