Hydroxycitric
Acid
Hydroxycitric acid (hydroxycitrate
or HCA) comes from the
tropical fruit Malabar tamarind (Garcinia
cambogia or brindleberry). Mitochondria
are the parts of our cells that make energy. Several chemical reactions
occur inside them. HCA blocks an enzyme called citrate
lyase in the mitochondria. This ends up causing carbohydrates to be
stored as glycogen
rather than as fat.
Hydroxycitric acid may also
decrease cholesterol
levels, increase energy expenditure, and
improve blood sugar levels. It is gaining popularity as a diabetes
supplement.
Studies
have conflicting results
about whether or not hydroxycitric acid causes weight loss. Therefore,
its use in weight loss is still unproven. However, there is some
positive evidence, and more studies need to be conducted.
This
supplement does seem to be well tolerated. However, there are some
potential
dangers. It should be used with caution in people who have diabetes and
are prone to having low blood sugars. It may have adverse effects in
people with Alzheimers.
For people taking a class of drugs called
statins (ex. Zocor, Lipitor, Crestor, lovastatin, etc.), it may
increase the risk of a side effect called rhabdomyolysis (muscle
breakdown).
It is
important you discuss any weight loss or exercise plan with your
doctor.
Only you and your physician can decide what is best for you. Some
people have certain conditions that prevent them from doing all
exercises, and goal body weights may be different for different people.
You need to discuss all these things with your physician before
starting any weight loss or exercise program. This article was
written by John
Vickery, MD.
References Am
Fam Physician. 2004 Nov 1;70(9):1731-8. Lexi-Comp database
accessed on 4/16/08 Prim Care Clin Office Pract.
2002 Jun;29(2)279-95. Int J Obes (Lond). 2005
Sep;29(9):1030-8. Aust Fam Physician. 2006 Aug;35(8):605-6. |