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Hydroxycitric Acid


Hydroxycitric acid (hydroxycitrate or HCA) comes from the tropical fruit Malabar tamarind (Garcinia cambogia or brindleberry). Mitochondria are the parts of our cells that make energy. Several chemical reactions occur inside them. HCA blocks an enzyme called citrate lyase in the mitochondria. This ends up causing carbohydrates to be stored as glycogen rather than as fat.

Hydroxycitric acid may also decrease cholesterol levels, increase energy expenditure, and improve blood sugar levels. It is gaining popularity as a diabetes supplement.

Studies have conflicting results about whether or not hydroxycitric acid causes weight loss. Therefore, its use in weight loss is still unproven. However, there is some positive evidence, and more studies need to be conducted.

This supplement does seem to be well tolerated. However, there are some potential dangers. It should be used with caution in people who have diabetes and are prone to having low blood sugars. It may have adverse effects in people with Alzheimers. For people taking a class of drugs called statins (ex. Zocor, Lipitor, Crestor, lovastatin, etc.), it may increase the risk of a side effect called rhabdomyolysis (muscle breakdown).
 

 


It is important you discuss any weight loss or exercise plan with your doctor. Only you and your physician can decide what is best for you. Some people have certain conditions that prevent them from doing all exercises, and goal body weights may be different for different people. You need to discuss all these things with your physician before starting any weight loss or exercise program.


This article was written by John Vickery, MD.


References

Am Fam Physician. 2004 Nov 1;70(9):1731-8.
Lexi-Comp database accessed on 4/16/08
Prim Care Clin Office Pract. 2002 Jun;29(2)279-95.
Int J Obes (Lond). 2005 Sep;29(9):1030-8.
Aust Fam Physician. 2006 Aug;35(8):605-6.