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BDNF
TrkB is a cell receptor that is
activated by
brain-derived neutrotrophic factor ( BDNF ). Brain-derived neutrotrophic
factor plays a role in
development of the hypothalamus, memory, behavior, and intellectual development.
Also, its levels are low in people who are fasting, and giving it to mice causes
them to eat less and lose weight.
In 2007, the first case report in humans was made. An eight
year old girl had a mutation in one copy of her BDNF genes. This caused her to
eat large amounts of food and become obese. She weighed more than 44 lbs at two
years of age. Additionally, she had memory problems, hyperactivity, difficulty
feeling pain, and cognitive impairment.
Return to Genetics or the
Home Page.
It is important you
discuss any weight loss or exercise plan with your doctor. Only you and
your physician can decide what is best for you. Some people have
certain conditions that prevent them from doing all exercises, and goal
body weights may be different for different people. You need to discuss
all these things with your physician before starting any weight loss or
exercise program.
This
article was written by
John
Vickery, MD.
References Endocrinol Metab Clin N Am
2008;37:733-751
Endocrine Reviews 27(7):710-718

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