logo for medical-weight-loss-guide.com
leftimage for medical-weight-loss-guide.com

BDNF


TrkB is a cell receptor that is activated by brain-derived neutrotrophic factor ( BDNF ). Brain-derived neutrotrophic factor plays a role in development of the hypothalamus, memory, behavior, and intellectual development. Also, its levels are low in people who are fasting, and giving it to mice causes them to eat less and lose weight.

In 2007, the first case report in humans was made. An eight year old girl had a mutation in one copy of her BDNF genes. This caused her to eat large amounts of food and become obese. She weighed more than 44 lbs at two years of age. Additionally, she had memory problems, hyperactivity, difficulty feeling pain, and cognitive impairment.

Return to Genetics or the Home Page.

It is important you discuss any weight loss or exercise plan with your doctor. Only you and your physician can decide what is best for you. Some people have certain conditions that prevent them from doing all exercises, and goal body weights may be different for different people. You need to discuss all these things with your physician before starting any weight loss or exercise program.

This article was written by John Vickery, MD.

References

Endocrinol Metab Clin N Am 2008;37:733-751
Endocrine Reviews 27(7):710-718

footer for Medical Weight Loss page

Site Build It!